Even after conducting clinical trials for years in central nervous diseases like schizophrenia, bipolar, depression, and Alzheimer’s Parkinson’s on various patients, clinicians are able to succeed in only the primary stage of the trials. There are two major reasons behind this repeating failures, one is the complexity of drugs to pass through the blood-brain barrier and reach the affected area. The other is the irregular intake of prescribed medication. Clinicians also found that 20 to 50 percent of people fail to take medication. Even after successive failures, clinicians were not fazed; they found an alternative way to counter this problem. This led to the development of personalized medicine. By the advent of personalized medicine, clinicians were able to treat the incurable diseases like bipolar and acute schizophrenia.

Furthermore, personalized medicine is advancing predominantly and constantly with the evolution of digital healthcare tools. Even a slight change in patient’s health can be easily detected with today’s digital technologies. Clinicians are also taking steps to train caregivers and patients to improve the reliability of patient’s reports. Additionally, clinicians are also patenting adaptive protocol designs ‘enhancing’ patient’s samples with complex screening methods which can bring out “drug-naïve” patients.